NYMC Faculty Publications
Pentose Shunt, Glucose-6-phosphate Dehydrogenase, NADPH Redox, and Stem Cells in Pulmonary Hypertension
DOI
10.1007/978-3-319-63245-2_4
Journal Title
Advances in Experimental Medicine and Biology
First Page
47
Last Page
55
Document Type
Article
Publication Date
January 2017
Department
Pharmacology
Abstract
Redox signaling plays a critical role in the pathophysiology of cardiovascular diseases. The pentose phosphate pathway is a major source of NADPH redox in the cell. The activities of glucose-6-phosphate dehydrogenase (the rate-limiting enzyme in the pentose shunt) and glucose flux through the shunt pathway is increased in various lung cells including, the stem cells, in pulmonary hypertension. This chapter discusses the importance of the shunt pathway and glucose-6-phosphate dehydrogenase in the pathogenesis of pulmonary artery remodeling and occlusive lesion formation within the hypertensive lungs.
Recommended Citation
Hashimoto, R., & Gupte, S. (2017). Pentose Shunt, Glucose-6-phosphate Dehydrogenase, NADPH Redox, and Stem Cells in Pulmonary Hypertension. Advances in Experimental Medicine and Biology, 967, 47-55. https://doi.org/10.1007/978-3-319-63245-2_4