NYMC Faculty Publications

Infections in Patients With a Total Artificial Heart Are Common but Rarely Fatal

DOI

10.1097/MAT.0000000000000562

Journal Title

ASAIO Journal (American Society for Artificial Internal Organs : 1992)

First Page

736

Last Page

739

Document Type

Article

Publication Date

November 2017

Department

Medicine

Abstract

Patients who received a total artificial heart (TAH) at Virginia Commonwealth University (VCU) between January 1, 2010 and December 31, 2011 were identified from the VCU Mechanical Circulatory Support Clinical Database. Retrospective data extraction from the medical records was performed from the time of TAH implantation until heart transplantation or death. Infections were classified as confirmed or suspected. Twenty-seven men and 5 women, mean age 49.5 years (range 24 to 68 years) received a TAH. The mean duration of TAH support was 225 days (range 1 to 1334 days). Of the 32 patients, 4 (12.5%) died and 28 (87.5 %) underwent heart transplantation. Causes of death were pneumonia (n=1), TAH malfunction (n=1), refractory cardiogenic shock (n=1), and respiratory failure (n=1). Seventy documented and 13 suspected infections developed in 25 patients (78%). The most common sources of infection were urinary tract (n=26), respiratory tract (n=18), and bloodstream (n=11). There were 5 pump infections and 2 drive line infections. The number of infections per patient ranged from 0 to 10. Sixteen different pathogens were identified; the most common were: Klebsiella pneumoniae (n=15), coagulase-negative Staphylococci (n=10), Enterococcus species (n=9) and Enterobacter species (n=8). Mortality directly attributable to infection was infrequent.

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