Treatment-resistant Schizophrenia: Treatment Response and Resistance in Psychosis (TRRIP) Working Group Consensus Guidelines on Diagnosis and Terminology

Authors

O Howes
R McCutcheon
O Agid
A de Bartolomeis
N van Beveren
M Birnbaum
Leslie Citrome, New York Medical CollegeFollow
F Leweke
B Ebdrup
H Elkis
P Falkai
W Fleischacker
A Gadelha
F Gaughran
B Glenthoj
A Graff-Guerrero
J Hallak
W Honer
J Kennedy
B Kinon
S Lawrie
J Lee
F Leweke
J MacCabe
C McNabb
H Meltzer
H Moller
S Nakajima
C Pantelis
T Reis Marques
G Remington
S Rossell
B Russell
C Siu
T Suzuki
I Sommer
D Taylor
N Thomas
A Ucok
D Umbricht
J Walters
J Kane
C Correll

DOI

10.1176/appi.ajp.2016.16050503

Journal Title

American Journal of Psychiatry

First Page

216

Last Page

229

Document Type

Article

Publication Date

March 2017

Department

Psychiatry and Behavioral Sciences

Abstract

OBJECTIVE: Research and clinical translation in schizophrenia is limited by inconsistent definitions of treatment resistance and response. To address this issue, the authors evaluated current approaches and then developed consensus criteria and guidelines. METHOD: A systematic review of randomized antipsychotic clinical trials in treatment-resistant schizophrenia was performed, and definitions of treatment resistance were extracted. Subsequently, consensus operationalized criteria were developed through 1) a multiphase, mixed methods approach, 2) identification of key criteria via an online survey, and 3) meetings to achieve consensus. RESULTS: Of 2,808 studies identified, 42 met inclusion criteria. Of these, 21 studies (50%) did not provide operationalized criteria. In the remaining studies, criteria varied considerably, particularly regarding symptom severity, prior treatment duration, and antipsychotic dosage thresholds; only two studies (5%) utilized the same criteria. The consensus group identified minimum and optimal criteria, employing the following principles: 1) current symptoms of a minimum duration and severity determined by a standardized rating scale; 2) moderate or worse functional impairment; 3) prior treatment consisting of at least two different antipsychotic trials, each for a minimum duration and dosage; 4) systematic monitoring of adherence and meeting of minimum adherence criteria; 5) ideally at least one prospective treatment trial; and 6) criteria that clearly separate responsive from treatment-resistant patients. CONCLUSIONS: There is considerable variation in current approaches to defining treatment resistance in schizophrenia. The authors present consensus guidelines that operationalize criteria for determining and reporting treatment resistance, adequate treatment, and treatment response, providing a benchmark for research and clinical translation.

Comments

Please see the work itself for the complete list of authors.

Recommended Citation

Howes, O., McCutcheon, R., Agid, O., de Bartolomeis, A., van Beveren, N., Birnbaum, M., Citrome, L., Leweke, F., Ebdrup, B., Elkis, H., Falkai, P., Fleischacker, W., Gadelha, A., Gaughran, F., Glenthoj, B., Graff-Guerrero, A., Hallak, J., Honer, W., Kennedy, J., Kinon, B., Lawrie, S., Lee, J., Leweke, F., MacCabe, J., McNabb, C., Meltzer, H., Moller, H., Nakajima, S., Pantelis, C., Reis Marques, T., Remington, G., Rossell, S., Russell, B., Siu, C., Suzuki, T., Sommer, I., Taylor, D., Thomas, N., Ucok, A., Umbricht, D., Walters, J., Kane, J., & Correll, C. (2017). Treatment-resistant Schizophrenia: Treatment Response and Resistance in Psychosis (TRRIP) Working Group Consensus Guidelines on Diagnosis and Terminology. American Journal of Psychiatry, 174 (3), 216-229. https://doi.org/10.1176/appi.ajp.2016.16050503