NYMC Faculty Publications
Cardiovascular Complications of Diabetes
Author Type(s)
Faculty, Resident/Fellow
DOI
10.1080/17446651.2022.2099838
Journal Title
Expert Review of Endocrinology & Metabolism
First Page
383
Last Page
388
Document Type
Review Article
Publication Date
9-2022
Department
Medicine
Abstract
INTRODUCTION: Type 2 diabetes mellitus (T2DM) is the ninth leading cause of mortality globally, and the prevalence continues to rise. Among individuals with T2DM, over two-thirds of deaths are caused by the cardiovascular complications of diabetes. These complications include atherosclerosis, coronary artery disease, nephropathy, stroke, thromboembolism, peripheral vascular disease. They have been long studied, and there are several theories as to the pathophysiology of how diabetes leads to these complications. The least understood mechanism is the pathophysiology linking diabetes to heart failure.
AREAS COVERED: This review focuses on the mechanisms of how T2DM leads to the aforementioned complications, particularly highlighting the development of heart failure. An extensive literature review of novel therapeutic options targeting the cardiovascular effects of T2DM was completed and summarized in this review.
EXPERT OPINION: This review finds that most studies to date have focused on the atherosclerotic vascular complications of diabetes. The pathophysiology between T2DM and heart failure is even less understood. Currently therapies that aim to decrease the risk of heart failure in diabetes are sparse. More research is required in order to better understand the changes at a cellular level and subsequently help providers to choose therapeutics that better target cardiovascular complications.
Recommended Citation
Shah, A., Isath, A., & Aronow, W. S. (2022). Cardiovascular Complications of Diabetes. Expert Review of Endocrinology & Metabolism, 17 (5), 383-388. https://doi.org/10.1080/17446651.2022.2099838