Andexanet Alfa Therapy Showed No Increased Rate of Thromboembolic Events in Spontaneous Intracranial Hemorrhage Patients: A Multicenter Electronic Health Record Study
Authors
John Vellek, School of Medicine, New York Medical College, Valhalla, NY, 10595, United States.
Omar H. Tarawneh, School of Medicine, New York Medical College, Valhalla, NY, 10595, United States.
Syed Faraz Kazim, Department of Neurosurgery, University of New Mexico Hospital (UNMH), Albuquerque, NM, 87131, United States.
Oluwafemi P. Owodunni, Department of Neurosurgery, University of New Mexico Hospital (UNMH), Albuquerque, NM, 87131, United States.
Sophia Arbuiso, School of Medicine, New York Medical College, Valhalla, NY, 10595, United States.Follow
Smit Shah, PRISMA Health Richland/University of South Carolina School of Medicine, 1 Medical Park, Suite 230, Columbia, SC, 29203, United States.
Alis J. Dicpinigaitis, School of Medicine, New York Medical College, Valhalla, NY, 10595, United States.
Meic H. Schmidt, Department of Neurosurgery, University of New Mexico Hospital (UNMH), Albuquerque, NM, 87131, United States.
Rohini G. McKee, Department of Surgery, University of New Mexico, Albuquerque, NM, 87106, United States.
Richard Miskimins, Department of Surgery, University of New Mexico, Albuquerque, NM, 87106, United States.
Fawaz Al-Mufti, Department of Neurosurgery, Westchester Medical Center/New York Medical College, Valhalla, NY, 10595, United States.Follow
Christian A. Bowers, Bowers Neurosurgical Frailty and Outcomes Data Science Lab, Sandy, UT, United States.
Author Type(s)
Student, Faculty
DOI
10.1016/j.wnsx.2024.100367
Journal Title
World Neurosurgery: X
Publication Date
7-1-2024
Keywords
Andexanet Alfa, Anticoagulation, Intracranial Hemorrhage, Thromboembolism
Disciplines
Medicine and Health Sciences
Abstract
•Intracranial hemorrhage accounts for two out of every three major intracranial hemorrhages.•Systemic anticoagulation is routinely prescribed for prevention of cerebrovascular accidents.•The FDA approved Andexanet alfa to treat life-threatening bleeding.•Andexanet alfa relationship to outcomes requires further investigation.
Recommended Citation
Vellek, J., Tarawneh, O. H., Kazim, S. F., Owodunni, O. P., Arbuiso, S., Shah, S., Dicpinigaitis, A. J., Schmidt, M. H., McKee, R. G., Miskimins, R., Al-Mufti, F., & Bowers, C. A.
(2024). Andexanet Alfa Therapy Showed No Increased Rate of Thromboembolic Events in Spontaneous Intracranial Hemorrhage Patients: A Multicenter Electronic Health Record Study. World Neurosurgery: X, 23, 100367.
https://doi.org/10.1016/j.wnsx.2024.100367
