Bilateral Tonic Pupils Secondary to Anti-Gd2 Antibody Therapy for Neuroblastoma

Authors

Christopher M. Edwards, University of Connecticut School of Medicine, Farmington, Connecticut. Electronic address: chedwards@uchc.edu.
Daniel Elefant, Department of Ophthalmology, New York Medical College, Westchester Medical Center, Valhalla, New York.
Michael S. Isakoff, Center for Cancer and Blood Disorders, Connecticut Children's, Hartford, Connecticut.
Majida A. Gaffar, University of Connecticut School of Medicine, Farmington, Connecticut; Division of Ophthalmology, Department of Surgery, Connecticut Children's, Hartford, Connecticut.

Author Type(s)

Faculty

DOI

10.1016/j.jaapos.2024.103852

Journal Title

Journal of AAPOS

First Page

103852

Document Type

Article

Publication Date

4-1-2024

Department

Ophthalmology

Abstract

We report the case of a 12-year-old girl with stage 4 neuroblastoma who developed tonic pupils secondary to immunotherapy with dinutuximab, an anti-GD2 antibody, based on the timeline provided by her mother with regard to onset of symptoms. The patient presented with difficulty reading and chronic dilated pupils bilaterally, according to her mother's observations over 6 months prior to presentation. Testing with dilute pilocarpine supported our presumption of tonic pupils.

Recommended Citation

Edwards, C. M., Elefant, D., Isakoff, M. S., & Gaffar, M. A. (2024). Bilateral Tonic Pupils Secondary to Anti-Gd2 Antibody Therapy for Neuroblastoma. Journal of AAPOS, 28 (2), 103852. https://doi.org/10.1016/j.jaapos.2024.103852