NYMC Faculty Publications
Cardiovascular Manifestations in Rheumatoid Arthritis
Author Type(s)
Faculty, Resident/Fellow, Student
DOI
10.1097/CRD.0000000000000486
Journal Title
Cardiology in Review
First Page
146
Last Page
152
Document Type
Article
Publication Date
3-1-2024
Department
Medicine
Abstract
Rheumatoid arthritis (RA) is a systemic inflammatory disorder that characteristically affects the joints. RA has extra-articular manifestations that can impact multiple organ systems including the heart, lungs, eyes, skin, and brain. Cardiovascular involvement is a leading cause of mortality in RA. Cardiovascular manifestations of RA include accelerated atherosclerosis, heart failure, pericarditis, myocarditis, endocarditis, rheumatoid nodules, and amyloidosis. Inflammation is an important mediator of endothelial dysfunction and is a key driver of cardiovascular risk and complications in patients with RA. Prompt identification of cardiac pathologies in patients with RA is essential for appropriate management and treatment. Choosing the most appropriate treatment regimen is based on individual patient factors. In this article, we provide a comprehensive review of the epidemiology, pathophysiology, clinical manifestations, diagnosis, and medical management of cardiovascular manifestations of RA. We also discuss the relationship between anti-rheumatic medications, specifically non-steroidal anti-inflammatory drugs, corticosteroids, methotrexate, statins, tumor necrosis factor inhibitors, interleukin-6 inhibitors, Janus kinase inhibitors, and cardiovascular disease.
Recommended Citation
Sanghavi, N., Ingrassia, J., Korem, S., Ash, J. Y., Pan, S., & Wasserman, A. (2024). Cardiovascular Manifestations in Rheumatoid Arthritis. Cardiology in Review, 32 (2), 146-152. https://doi.org/10.1097/CRD.0000000000000486
