Adoptive Cellular Therapy After Hematopoietic Stem Cell Transplantation

Authors

Pongthep Vittayawacharin, Hematopoietic Stem Cell Transplantation and Cellular Therapy Program, Division of Hematology/Oncology, Department of Medicine, University of California, Irvine, Orange, California, USA.
Piyanuch Kongtim, Hematopoietic Stem Cell Transplantation and Cellular Therapy Program, Division of Hematology/Oncology, Department of Medicine, University of California, Irvine, Orange, California, USA.
Yaya Chu, Department of Pediatrics, New York Medical College, Valhalla, New York, USA.Follow
Carl H. June, Department of Pathology and Laboratory Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Catherine M. Bollard, Center for Cancer and Immunology Research, Children's National Hospital and The George Washington University, Washington, DC, USA.
Stefan O. Ciurea, Hematopoietic Stem Cell Transplantation and Cellular Therapy Program, Division of Hematology/Oncology, Department of Medicine, University of California, Irvine, Orange, California, USA.

Author Type(s)

Faculty

DOI

10.1002/ajh.27204

Journal Title

American Journal of Hematology

First Page

910

Last Page

921

Document Type

Article

Publication Date

5-1-2024

Department

Pediatrics

Abstract

Effective cellular therapy using CD19 chimeric antigen receptor T-cells for the treatment of advanced B-cell malignancies raises the question of whether the administration of adoptive cellular therapy (ACT) posttransplant could reduce relapse and improve survival. Moreover, several early phase clinical studies have shown the potential beneficial effects of administration of tumor-associated antigen-specific T-cells and natural killer cells posttransplant for high-risk patients, aiming to decrease relapse and possibly improve survival. In this article, we present an in-depth review of ACT after transplantation, which has the potential to significantly improve the efficacy of this procedure and revolutionize this field.

Recommended Citation

Vittayawacharin, P., Kongtim, P., Chu, Y., June, C. H., Bollard, C. M., & Ciurea, S. O. (2024). Adoptive Cellular Therapy After Hematopoietic Stem Cell Transplantation. American Journal of Hematology, 99 (5), 910-921. https://doi.org/10.1002/ajh.27204