NYMC Faculty Publications
Shorter versus Longer Duration of Antimicrobial Therapy for Early Lyme Disease: A Systematic Review and Meta-Analysis
Author Type(s)
Faculty
DOI
10.1016/j.diagmicrobio.2024.116215
Journal Title
Diagnostic Microbiology and Infectious Disease
First Page
116215
Document Type
Article
Publication Date
6-1-2024
Department
Medicine
Abstract
BACKGROUND: Antibiotic therapy for patients with early Lyme disease is necessary to prevent later-stage Lyme disease complications. This systematic review and meta-analysis compares shorter versus longer antibiotic regimens in treating early Lyme disease. METHODS: A systematic search of PubMed, Embase, and Cochrane Central Register of Controlled Trials was conducted up to November 2023. We examined treatment failure, complete response, and photosensitivity. Short vs. long therapy was defined as ≤10 days vs. >10 days. Subgroup analyses included antibiotic type and varying treatment durations. Analysis utilized RStudio 4.1.2. PROSPERO registration: CRD42023423876. RESULTS: Seven studies, encompassing 1,462 patients, were analyzed. No significant differences in treatment failure, 12-month complete response, final visit complete response were found between short and long durations of antibiotic therapy. Subgroup and sensitivity analyses corroborated these findings. CONCLUSION: Shorter and longer antibiotic regimens for early Lyme disease show similar efficacy, highlighting the potential of ≤10-day courses, as effective treatment options.
Recommended Citation
Roca Mora, M. M., Cunha, L. M., Godoi, A., Donadon, I., Clemente, M., Marcolin, P., Valenzuela S, A., & Wormser, G. P. (2024). Shorter versus Longer Duration of Antimicrobial Therapy for Early Lyme Disease: A Systematic Review and Meta-Analysis. Diagnostic Microbiology and Infectious Disease, 109 (2), 116215. https://doi.org/10.1016/j.diagmicrobio.2024.116215