NYMC Faculty Publications
Impella Devices: A Comprehensive Review of Their Development, Use, and Impact on Cardiogenic Shock and High-Risk Percutaneous Coronary Intervention
Author Type(s)
Resident/Fellow, Faculty
DOI
10.1080/14779072.2023.2244874
Journal Title
Expert Review of Cardiovascular Therapy
First Page
613
Last Page
620
Document Type
Article
Publication Date
1-1-2023
Department
Medicine
Abstract
INTRODUCTION: Impella devices have emerged as a critical tool for temporary mechanical circulatory support (TMCS) in the management of cardiogenic shock (CS) and high-risk percutaneous coronary interventions (PCI). The purpose of this review is to examine the history of the different Impella devices, their hemodynamic profiles, and how the data supports their use. AREAS COVERED: This review covers the development and specifications of the Impella 2.5, Impella CP, Impella 5.0/Left Direct (LD), Impella RP, and Impella 5.5 devices. This review also covers the clinical trials that illuminate the Impella devices' use in their appropriate clinical contexts. These studies examine the effectiveness of Impella devices and have begun to yield promising results, demonstrating improved survival rates when compared to the historically high mortality rates associated with CS. It is important to weigh the benefits of Impella devices in light of their contraindications. A literature search was conducted by searching the PubMed database for reviews, meta-analyses, and clinical trials pertinent to Impella devices. EXPERT OPINION: Impella devices are a crucial tool for management of patients undergoing high-risk PCI and those with CS. There is evidence that early Impella implantation is beneficial in the treatment of patients presenting with CS. Further randomized controlled trials are needed to better elucidate the benefits of Impella devices in various clinical settings.
Recommended Citation
Fishkin, T., Isath, A., Naami, E., Aronow, W. S., Levine, A., & Gass, A. (2023). Impella Devices: A Comprehensive Review of Their Development, Use, and Impact on Cardiogenic Shock and High-Risk Percutaneous Coronary Intervention. Expert Review of Cardiovascular Therapy, 21 (9), 613-620. https://doi.org/10.1080/14779072.2023.2244874