Stress-Induced Premature Senescence of Endothelial and Endothelial Progenitor Cells

Authors

M S. Goligorsky, New York Medical College at Touro University, Valhalla, NY, United States; Yale University, New Haven, CT, United States. Electronic address: michael_goligorsky@nymc.edu.Follow
K Hirschi, New York Medical College at Touro University, Valhalla, NY, United States; Yale University, New Haven, CT, United States. Electronic address: Karen.Hirschi@yale.edu.

Author Type(s)

Faculty

DOI

10.1016/bs.apha.2016.04.007

Journal Title

Advances in Pharmacology

First Page

281

Last Page

306

Document Type

Article

Publication Date

1-1-2016

Keywords

Endothelial cell metabolism, Endothelial rejuvenation, Endothelial–mesenchymal transition, Microvascular endowment and rarefaction, Senescence-associated secretory products, Warburg metabolism

Disciplines

Medicine and Health Sciences

Abstract

This brief overview of premature senescence of dysfunctional endothelial and endothelial progenitor cells provides information on endothelial cell differentiation and specialization, their ontogeny, and controversies related to endothelial stem and progenitor cells. Stressors responsible for the dysfunction of endothelial and endothelial progenitor cells, as well as cellular mechanisms and consequences of endothelial cell dysfunction are presented. Metabolic signatures of dysfunctional endothelial cells and senescence pathways are described. Emerging strategies to rejuvenate endothelial and endothelial progenitor cells conclude the review.

Recommended Citation

Goligorsky, M. S., & Hirschi, K. (2016). Stress-Induced Premature Senescence of Endothelial and Endothelial Progenitor Cells. Advances in Pharmacology, 77, 281-306. https://doi.org/10.1016/bs.apha.2016.04.007