NYMC Faculty Publications
Borrelia Burgdorferi Pathogenesis and the Immune Response
Author Type(s)
Faculty
DOI
10.1016/j.cll.2015.07.004
Journal Title
Clinics in Laboratory Medicine
First Page
745
Last Page
64
Document Type
Article
Publication Date
12-1-2015
Abstract
Borrelia burgdorferi is the tick-borne etiologic agent of Lyme disease. The spirochete must negotiate numerous barriers in order to establish a disseminated infection in a mammalian host. These barriers include migration from the feeding tick midgut to the salivary glands, deposition in skin, manipulation or evasion of the localized host immune response, adhesion to and extravasation through an endothelial barrier, hematogenous dissemination, and establishment of infection in distal tissue sites. Borrelia burgdorferi proteins that mediate many of these processes and the nature of the host response to infection are described.
Recommended Citation
Petzke, M., & Schwartz, I. (2015). Borrelia Burgdorferi Pathogenesis and the Immune Response. Clinics in Laboratory Medicine, 35 (4), 745-64. https://doi.org/10.1016/j.cll.2015.07.004