NYMC Faculty Publications
ABT-199 (Venetoclax) and BCL-2 Inhibitors in Clinical Development
Author Type(s)
Faculty
DOI
10.1186/s13045-015-0224-3
Journal Title
Journal of Hematology & Oncology
First Page
129
Document Type
Article
Publication Date
11-20-2015
Abstract
With the advent of new agents targeting CD20, Bruton's tyrosine kinase, and phosphoinositol-3 kinase for chronic lymphoid leukemia (CLL), more treatment options exist than ever before. B-cell lymphoma-2 (BCL-2) plays a major role in cellular apoptosis and is a druggable target. Small molecule inhibitors of BCL-2 are in active clinical studies. ABT-199 (venetoclax, RG7601, GDC-0199) has been granted breakthrough designation by FDA for relapsed or refractory CLL with 17p deletion. In this review, we summarized the latest clinical development of ABT-199/venetoclax and other novel agents targeting the BCL-2 proteins.
Recommended Citation
Cang, S., Iragavarapu, C., Savooji, J., Song, Y., & Liu, D. (2015). ABT-199 (Venetoclax) and BCL-2 Inhibitors in Clinical Development. Journal of Hematology & Oncology, 8, 129. https://doi.org/10.1186/s13045-015-0224-3