The Cell Secretome, a Mediator of Cell-To-Cell Communication

Authors

Joseph Zullo, Departments of Medicine, Pharmacology and Physiology, Renal Research Institute, New York Medical College, Valhalla, NY 10595, USA.
Kei Matsumoto, Departments of Medicine, Pharmacology and Physiology, Renal Research Institute, New York Medical College, Valhalla, NY 10595, USA.
Sandhya Xavier, Departments of Medicine, Pharmacology and Physiology, Renal Research Institute, New York Medical College, Valhalla, NY 10595, USA.
Brian Ratliff, Departments of Medicine, Pharmacology and Physiology, Renal Research Institute, New York Medical College, Valhalla, NY 10595, USA.
Michael S. Goligorsky, Departments of Medicine, Pharmacology and Physiology, Renal Research Institute, New York Medical College, Valhalla, NY 10595, USA. Electronic address: Michael_goligorsky@nymc.edu.

Author Type(s)

Faculty

DOI

10.1016/j.prostaglandins.2015.03.012

Journal Title

Prostaglandins & Other Lipid Mediators

First Page

17

Last Page

20

Document Type

Article

Publication Date

7-1-2015

Abstract

We are witnessing the emergence of a novel type of biological regulation, namely, the communication between cells via their secreted substances, the secretome. This brief overview is based on the available published data and our own experience. We discuss three vignettes illustrating the importance of communication via the secretome: (1) the secretome of stem cells and its effects in sepsis and systemic inflammatory response; (2) the profibrotic secretomes partially responsible for development of fibrotic complications; and (3) the contribution of senescence-associated secretory products to the propagation of the senescence phenotype. Considering the richness of secretomes of different cells under diverse conditions, it becomes imperative to gain insights into their individual components in an attempt to harness cell secretomes for therapeutic purposes.

Recommended Citation

Zullo, J., Matsumoto, K., Xavier, S., Ratliff, B., & Goligorsky, M. S. (2015). The Cell Secretome, a Mediator of Cell-To-Cell Communication. Prostaglandins & Other Lipid Mediators, 120, 17-20. https://doi.org/10.1016/j.prostaglandins.2015.03.012