Molecular Epidemiology and Genomics of Group a Streptococcus

Authors

Debra E. Bessen, Department of Microbiology & Immunology, New York Medical College, Valhalla, NY 10595, USA. Electronic address: debra_bessen@nymc.edu.
W Michael McShan, University of Oklahoma Health Sciences Center, Department of Pharmaceutical Sciences, College of Pharmacy, Oklahoma City, OK 73117, USA. Electronic address: William-McShan@ouhsc.edu.
Scott V. Nguyen, University of Oklahoma Health Sciences Center, Department of Pharmaceutical Sciences, College of Pharmacy, Oklahoma City, OK 73117, USA. Electronic address: Scott-Van-Nguyen@ouhsc.edu.
Amol Shetty, Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: AShetty@som.umaryland.edu.
Sonia Agrawal, Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: SAgrawal@som.umaryland.edu.
Hervé Tettelin, Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: tettelin@som.umaryland.edu.

Author Type(s)

Faculty

DOI

10.1016/j.meegid.2014.10.011

Journal Title

Infection, Genetics and Evolution

First Page

393

Last Page

418

Document Type

Article

Publication Date

7-1-2015

Abstract

Streptococcus pyogenes (group A Streptococcus; GAS) is a strict human pathogen with a very high prevalence worldwide. This review highlights the genetic organization of the species and the important ecological considerations that impact its evolution. Recent advances are presented on the topics of molecular epidemiology, population biology, molecular basis for genetic change, genome structure and genetic flux, phylogenomics and closely related streptococcal species, and the long- and short-term evolution of GAS. The application of whole genome sequence data to addressing key biological questions is discussed.

Recommended Citation

Bessen, D. E., McShan, W. M., Nguyen, S. V., Shetty, A., Agrawal, S., & Tettelin, H. (2015). Molecular Epidemiology and Genomics of Group a Streptococcus. Infection, Genetics and Evolution, 33, 393-418. https://doi.org/10.1016/j.meegid.2014.10.011