NYMC Faculty Publications

Obesity Susceptibility Loci in Qataris, a Highly Consanguineous Arabian Population

Sara Tomei, Department of Genetic Medicine, Laboratory of Genetic Medicine & Immunology, Weill Cornell Medical College in Qatar, Al Luqta Street, Qatar Foundation, Education City, Doha, Qatar, PO 24144. stomei@sidra.org.
Ravinder Mamtani, Global and Public Health Department, Weill Cornell Medical College in Qatar, Doha, Qatar. ram2026@qatar-med.cornell.edu.
Rashid Al Ali, Sidra Medical and Research Center, Research Branch, Al Nasr Tower, Al Corniche Street, Qatar Foundation, Doha, Qatar, PO 26999. ralali@sidra.org.
Naser Elkum, Sidra Medical and Research Center, Research Branch, Al Nasr Tower, Al Corniche Street, Qatar Foundation, Doha, Qatar, PO 26999. nelkum@sidra.org.
Maryam Abdulmalik, Primary Health Care Corporation, Doha, Qatar. mabdulmalik@phcc.gov.qa.
Awatef Ismail, Global and Public Health Department, Weill Cornell Medical College in Qatar, Doha, Qatar. achouchn@yahoo.fr.
Sohaila Cheema, Global and Public Health Department, Weill Cornell Medical College in Qatar, Doha, Qatar. soc2005@qatar-med.cornell.edu.
Hekmat A. Rouh, Global and Public Health Department, Weill Cornell Medical College in Qatar, Doha, Qatar. har2005@qatar-med.cornell.edu.
Idil I. Aigha, Department of Genetic Medicine, Laboratory of Genetic Medicine & Immunology, Weill Cornell Medical College in Qatar, Al Luqta Street, Qatar Foundation, Education City, Doha, Qatar, PO 24144. idilucha@gmail.com.
Fatima Hani, Department of Genetic Medicine, Laboratory of Genetic Medicine & Immunology, Weill Cornell Medical College in Qatar, Al Luqta Street, Qatar Foundation, Education City, Doha, Qatar, PO 24144. fatma-m-hani@hotmail.com.
Sura Al-Samraye, Global and Public Health Department, Weill Cornell Medical College in Qatar, Doha, Qatar. sha2038@qatar-med.cornell.edu.
Mona Taher Aseel, Primary Health Care Corporation, Doha, Qatar. MASEEL@phcc.gov.qa.
Nada El Emadi, Primary Health Care Corporation, Doha, Qatar. nemadi@phcc.gov.qa.
Azza Al Mujalli, Primary Health Care Corporation, Doha, Qatar. aasaad@phcc.gov.qa.
Ahmed Abdelkerim, Primary Health Care Corporation, Doha, Qatar. akarim@phcc.gov.qa.
Siddik Youssif, Primary Health Care Corporation, Doha, Qatar. sosman@phcc.gov.qa.
Andrea Worschech, Department of Genetic Medicine, Laboratory of Genetic Medicine & Immunology, Weill Cornell Medical College in Qatar, Al Luqta Street, Qatar Foundation, Education City, Doha, Qatar, PO 24144. anw2028@qatar-med.cornell.edu.
Emad El Sebakhy, Sidra Medical and Research Center, Research Branch, Al Nasr Tower, Al Corniche Street, Qatar Foundation, Doha, Qatar, PO 26999. eelsebakhy@sidra.org.
Ramzi Temanni, Sidra Medical and Research Center, Research Branch, Al Nasr Tower, Al Corniche Street, Qatar Foundation, Doha, Qatar, PO 26999. rtemanni@sidra.org.
Vineesh Khanna, Sidra Medical and Research Center, Research Branch, Al Nasr Tower, Al Corniche Street, Qatar Foundation, Doha, Qatar, PO 26999. vkhanna@sidra.org.
Ena Wang, Sidra Medical and Research Center, Research Branch, Al Nasr Tower, Al Corniche Street, Qatar Foundation, Doha, Qatar, PO 26999. ewang@sidra.org.
Dhanya Kizhakayil, Department of Genetic Medicine, Laboratory of Genetic Medicine & Immunology, Weill Cornell Medical College in Qatar, Al Luqta Street, Qatar Foundation, Education City, Doha, Qatar, PO 24144. dhanyabiotech@gmail.com.
Al-Anood Al-Thani, Supreme Council of Health, Doha, Qatar. aalthani@sch.gov.qa.
Mohammed Al-Thani, Supreme Council of Health, Doha, Qatar. malthani@sch.gov.qa.
Albert Lowenfels, New York Medical College, New York, USA. Lowenfels@nymc.edu.
Francesco M. Marincola, Sidra Medical and Research Center, Research Branch, Al Nasr Tower, Al Corniche Street, Qatar Foundation, Doha, Qatar, PO 26999. fmarincola@sidra.org.
Javaid Sheikh, Dean's Office, Weill Cornell Medical College in Qatar, Doha, Qatar. jis2011@med.cornell.edu.
Lotfi Chouchane, Department of Genetic Medicine, Laboratory of Genetic Medicine & Immunology, Weill Cornell Medical College in Qatar, Al Luqta Street, Qatar Foundation, Education City, Doha, Qatar, PO 24144. loc2008@qatar-med.cornell.edu.

Author Type(s)

Faculty

DOI

10.1186/s12967-015-0459-3

Journal Title

Journal of Translational Medicine

First Page

119

Document Type

Article

Publication Date

4-13-2015

Abstract

OBJECTIVES: In Qataris, a population characterized by a small size and a high rate of consanguinity, between two-thirds to three-quarters of adults are overweight or obese. We investigated the relevance of 23 obesity-related loci in the Qatari population. METHODS: Eight-hundred-four individuals assessed to be third generation Qataris were included in the study and assigned to 3 groups according to their body mass index (BMI): 190 lean (BMI < 25 kg/m(2)); 131 overweight (25 kg/m(2) ≤ BMI < 30 kg/m(2)) and 483 obese (BMI ≥ 30 kg/m(2)). Genomic DNA was isolated from peripheral blood and genotyped by TaqMan. RESULTS: Two loci significantly associated with obesity in Qataris: the TFAP2B variation (rs987237) (A allele versus G allele: chi-square = 10.3; P = 0.0013) and GNPDA2 variation (rs10938397) (A allele versus G allele: chi-square = 6.15; P = 0.013). The TFAP2B GG genotype negatively associated with obesity (OR = 0.21; P = 0.0031). Conversely, the GNDPA2 GG homozygous genotype associated with higher risk of obesity in subjects of age < 32 years (P = 0.0358). CONCLUSION: We showed a different genetic profile associated with obesity in the Qatari population compared to Western populations. Studying the genetic background of Qataris is of primary importance as the etiology of a given disease might be population-specific.

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