Selective Inhibitors of Nuclear Export (SINE)--A Novel Class of Anti-Cancer Agents

Authors

Kaushal Parikh
Shundong Cang
Arunabh Sekhri
Delong Liu, Henan Tumor Hospital, Zhengzhou University, Zhengzhou, China. Delong_liu@nymc.edu.

Author Type(s)

Faculty

DOI

10.1186/s13045-014-0078-0

Journal Title

Journal of Hematology & Oncology

First Page

78

Document Type

Article

Publication Date

10-15-2014

Abstract

Dysregulation of the nucleo-cytoplasmic transport of proteins plays an important role in carcinogenesis. The nuclear export of proteins depends on the activity of transport proteins, exportins. Exportins belong to the karyopherin β superfamily. Exportin-1 (XPO1), also known as chromosomal region maintenance 1 (CRM1), mediates transport of around 220 proteins. In this review, we summarized the development of a new class of antitumor drugs, collectively known as selective inhibitors of nuclear export (SINE). KPT-330 (selinexor) as an oral agent is showing activities in early clinical trials in both solid tumors and hematological malignancies.

Recommended Citation

Parikh, K., Cang, S., Sekhri, A., & Liu, D. (2014). Selective Inhibitors of Nuclear Export (SINE)--A Novel Class of Anti-Cancer Agents. Journal of Hematology & Oncology, 7, 78. https://doi.org/10.1186/s13045-014-0078-0