Relationship Between Sweat Chloride, Sodium, and Age in Clinically Obtained Samples

Authors

Nadav Traeger, New York Medical College, Department of Pediatrics, Division of Pediatric Pulmonology, Allergy, and Sleep Medicine Munger Pavilion Room 106, Valhalla, NY 10595, United States; The Armond V. Mascia, MD Cystic Fibrosis Center of the Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, NY, United States. Electronic address: nadav_traeger@nymc.edu.
Qiuhu Shi, New York Medical College, Department of Epidemiology and Community Health, School of Health Sciences and Practice, Valhalla, NY 10595, United States.
Allen J. Dozor, New York Medical College, Department of Pediatrics, Division of Pediatric Pulmonology, Allergy, and Sleep Medicine Munger Pavilion Room 106, Valhalla, NY 10595, United States; The Armond V. Mascia, MD Cystic Fibrosis Center of the Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, NY, United States.

Author Type(s)

Faculty

DOI

10.1016/j.jcf.2013.07.003

Journal Title

Journal of Cystic Fibrosis

First Page

10

Last Page

4

Document Type

Article

Publication Date

1-1-2014

Abstract

BACKGROUND: The relationship between sweat electrolytes and age is uncertain, as is the value of measuring sodium or the chloride:sodium ratio. METHODS: 13,785 sweat tests performed over 23 years at one center through the Macroduct collection in clinically obtained samples were analyzed. RESULTS: Sweat chloride tended to decrease over the first year of life, slowly increase until the fourth decade, then either level off or slightly decrease. In children, sweat sodium overlapped between those with positive and negative sweat tests, but not in adults. If the sweat test was positive, there was a higher likelihood of having a chloride:sodium ratio >1, but most subjects with a ratio >1 did not have CF. CONCLUSIONS: Sweat chloride and sodium vary with age. Measurement of sweat sodium did not add discriminatory value. The proportion of subjects with a chloride:sodium ratio >1, with or without CF, varied greatly between age ranges.

Recommended Citation

Traeger, N., Shi, Q., & Dozor, A. J. (2014). Relationship Between Sweat Chloride, Sodium, and Age in Clinically Obtained Samples. Journal of Cystic Fibrosis, 13 (1), 10-4. https://doi.org/10.1016/j.jcf.2013.07.003