NYMC Faculty Publications
Gonadal Status-Dependent Effects of in Vivo Β-Estradiol Administration to Female Rats on in Vitro Epileptiform Activity Induced by Low [Mg2+]₀ in Combined Hippocampus-Entorhinal Cortex Slices
Author Type(s)
Faculty
DOI
10.1016/j.eplepsyres.2013.09.002
Journal Title
Epilepsy Research
First Page
297
Last Page
301
Document Type
Article
Publication Date
12-1-2013
Abstract
There are controversial data regarding estrogen effects on neuronal excitability. We investigated whether β-estradiol (EB) administration to ovariectomized (OVX) or gonadally intact female rats alters epileptiform activity within the dentate gyrus network induced in vitro by removing [Mg2+]o in combined hippocampus-entorhinal cortex slices. In vivo EB administration significantly influenced the epileptiform activity in gonadal status-dependent manner. The onset of epileptiform discharges was modestly delayed in slices from OVX rats replaced with physiologically relevant doses of EB but the number of discharges was not affected. In contrast, EB administration to gonadally intact rats had robust effects such that: EB delayed the onset of discharges but significantly increased their number within the dentate gyrus network. Our data suggest that EB in physiologically relevant concentrations does not seem to negatively affect hippocampal neuronal excitability, nevertheless supraphysiological EB levels may enhance seizure severity.
Recommended Citation
Velíšková, J., & Velíšek, L. (2013). Gonadal Status-Dependent Effects of in Vivo Β-Estradiol Administration to Female Rats on in Vitro Epileptiform Activity Induced by Low [Mg2+]₀ in Combined Hippocampus-Entorhinal Cortex Slices. Epilepsy Research, 107 (3), 297-301. https://doi.org/10.1016/j.eplepsyres.2013.09.002