NYMC Faculty Publications
Evidence for Novel Aspects of Nox4 Oxidase Regulation of Mitochondrial Function and Peroxide Generation in an Endothelial Cell Model of Senescence
Author Type(s)
Faculty
DOI
10.1042/BJ20130484
Journal Title
The Biochemical Journal
First Page
e1
Last Page
2
Document Type
Article
Publication Date
6-1-2013
Abstract
Observations by Kozieł et al. reported in this issue of the Biochemical Journal suggest the existence of novel regulatory processes associated with new evidence for increased Nox4 (NAPDH oxidase 4) regulation of mitochondrial function in a cultured endothelial cell aging-induced senescence model. Cellular aging appears to promote a Nox4 interaction with mitochondria that disrupts complex I in the electron transport chain and increases the detection of mitochondrial H(2)O(2). Nox4 appears to maintain a highly interconnected mitochondrial network, which may influence mitochondrial fission and/or fusion mechanisms in a manner that could be a contributing factor in the loss of replicative lifespan seen in senescence.
Recommended Citation
Wolin, M. S. (2013). Evidence for Novel Aspects of Nox4 Oxidase Regulation of Mitochondrial Function and Peroxide Generation in an Endothelial Cell Model of Senescence. The Biochemical Journal, 452 (2), e1-2. https://doi.org/10.1042/BJ20130484