NYMC Faculty Publications
Messengers Without Borders: Mediators of Systemic Inflammatory Response in AKI
Author Type(s)
Faculty
DOI
10.1681/ASN.2012060633
Journal Title
Journal of the American Society of Nephrology
First Page
529
Last Page
36
Document Type
Article
Publication Date
3-1-2013
Abstract
The list of signals sent by an injured organ to systemic circulation, so-called danger signals, is growing to include multiple metabolites and secreted moieties, thus revealing a highly complex and integrated network of interlinked systemic proinflammatory and proregenerative messages. Emerging new data indicate that, apart from the well established local inflammatory response to AKI, danger signaling unleashes a cascade of precisely timed, interdependent, and intensity-gradated mediators responsible for development of the systemic inflammatory response. This fledgling realization of the importance of the systemic inflammatory response to the localized injury and inflammation is at the core of this brief overview. It has a potential to explain the additive effects of concomitant diseases or preexisting chronic conditions that can prime the systemic inflammatory response and exacerbate it out of proportion to the actual degree of acute kidney damage. Although therapies for ameliorating AKI per se remain limited, a potentially powerful strategy that could reap significant benefits in the future is to modulate the intensity of danger signals and consequently the systemic inflammatory response, while preserving its intrinsic proregenerative stimuli.
Recommended Citation
Ratliff, B. B., Rabadi, M. M., Vasko, R., Yasuda, K., & Goligorsky, M. S. (2013). Messengers Without Borders: Mediators of Systemic Inflammatory Response in AKI. Journal of the American Society of Nephrology, 24 (4), 529-36. https://doi.org/10.1681/ASN.2012060633