NYMC Faculty Publications
Follicular Skin Disorders, Inflammatory Bowel Disease, and the Microbiome: A Systematic Review
Author Type(s)
Student, Resident/Fellow, Faculty
DOI
10.3390/ijms251810203
Journal Title
International Journal of Molecular Sciences
Document Type
Article
Publication Date
9-23-2024
Department
Health Sciences Library
Second Department
Dermatology
Abstract
Follicular skin disorders, including hidradenitis suppurativa (HS), frequently coexist with systemic autoinflammatory diseases, such as inflammatory bowel disease (IBD) and its subtypes, Crohn's disease and ulcerative colitis. Previous studies suggest that dysbiosis of the human gut microbiome may serve as a pathogenic link between HS and IBD. However, the role of the microbiome (gut, skin, and blood) in the context of IBD and various follicular disorders remains underexplored. Here, we performed a systematic review to investigate the relationship between follicular skin disorders, IBD, and the microbiome. Of the sixteen included studies, four evaluated the impact of diet on the microbiome in HS patients, highlighting a possible link between gut dysbiosis and yeast-exclusion diets. Ten studies explored bacterial colonization and HS severity with specific gut and skin microbiota, including Enterococcus and Veillonella. Two studies reported on immunological or serological biomarkers in HS patients with autoinflammatory disease, including IBD, and identified common markers including elevated cytokines and T-lymphocytes. Six studies investigated HS and IBD patients concurrently. Our systematic literature review highlights the complex interplay between the human microbiome, IBD, and follicular disorders with a particular focus on HS. The results indicate that dietary modifications hold promise as a therapeutic intervention to mitigate the burden of HS and IBD. Microbiota analyses and the identification of key serological biomarkers are crucial for a deeper understanding of the impact of dysbiosis in these conditions. Future research is needed to more thoroughly delineate the causal versus associative roles of dysbiosis in patients with both follicular disorders and IBD.
Recommended Citation
Fleshner, L., Roster, K., Farabi, B., Hirani, R., Tepper, K., Pitchumoni, C. S., Safai, B., & Marmon, S. (2024). Follicular Skin Disorders, Inflammatory Bowel Disease, and the Microbiome: A Systematic Review. International Journal of Molecular Sciences, 25 (18). https://doi.org/10.3390/ijms251810203