NYMC Faculty Publications
Doxycycline Affects Diet- and Bacteria-Associated Atherosclerosis in An ApoE Heterozygote Murine Model: Cytokine Profiling Implications
Author Type(s)
Faculty
Additional Author Affiliation
Touro College of Dental Medicine at NYMC
DOI
10.1016/j.atherosclerosis.2006.02.026
Journal Title
Atherosclerosis
First Page
62
Last Page
72
Document Type
Article
Publication Date
1-1-2007
Department
Pharmacology
Abstract
BACKGROUND: It has been postulated that systemic infection with pathogens such as Porphyromonas gingivalis (Pg) elevates the inflammatory response and increases susceptibility to atherosclerosis. We hypothesized that Doxycycline would be beneficial in diet- and/or Pg-induced atherosclerosis given its role in various cell functions and matrix remodeling.
METHODS AND RESULTS: ApoE+/- mice were inoculated weekly with Pg and treated with either Doxycycline or saline; animals were fed either a high-fat or chow diet. Animals were euthanized at 14 or 24 weeks and histomorphometric analysis of atheromatous lesions in proximal aorta, levels of SAA and serum cytokine profiling were performed. Histomorphometric analysis demonstrated that in non-infected mice fed a high fat diet, Doxycycline treatment resulted in a reduction of mean lesions from 10.5%+/-.49 to 1.09%+/-0.102 (p
CONCLUSIONS: Doxycycline decreases pro-inflammatory cytokines and results in reduction of atherosclerosis in ApoE+/-Pg-inoculated and/or high fat diet fed mice.
Recommended Citation
Madan, M., Bishayi, B., Hoge, M., Messas, E., & Amar, S. (2007). Doxycycline Affects Diet- and Bacteria-Associated Atherosclerosis in An ApoE Heterozygote Murine Model: Cytokine Profiling Implications. Atherosclerosis, 190 (1), 62-72. https://doi.org/10.1016/j.atherosclerosis.2006.02.026
