NYMC Faculty Publications
An Application of Monotone Functions Decomposition to the Reconstruction of Gene Regulatory Networks
Author Type(s)
Faculty
Additional Author Affiliation
Touro College of Dental Medicine at NYMC
DOI
10.1109/IEMBS.2011.6090676
Journal Title
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society
First Page
2430
Last Page
2433
Document Type
Article
Publication Date
1-1-2011
Department
Pharmacology
Abstract
We describe the reconstruction of a gene regulatory network involved with the Toll-like Receptor signaling pathways. By applying our recent identification algorithm to a time series gene expression dataset, we identify regulatory interactions between genes and construct discrete-time piece-wise affine regulatory functions. Our validation shows that our model predicts the expression levels of the genes involved in the network with good accuracy.
Recommended Citation
Chang, H., Richard, G., Julius, A., Belta, C., & Amar, S. (2011). An Application of Monotone Functions Decomposition to the Reconstruction of Gene Regulatory Networks. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2011, 2430-2433. https://doi.org/10.1109/IEMBS.2011.6090676
