NYMC Faculty Publications
LITAF Mediation of Increased TNF-α Secretion From Inflamed Colonic Lamina Propria Macrophages
Author Type(s)
Faculty
Additional Author Affiliation
Touro College of Dental Medicine at NYMC
DOI
10.1371/journal.pone.0025849
Journal Title
PLoS One
First Page
25849
Last Page
25849
Document Type
Article
Publication Date
1-1-2011
Department
Pharmacology
Abstract
Dysregulation of TNF-α in lamina propria macrophages (LPM) is a feature of inflammatory bowel diseases (IBD). LPS-Induced-TNF-Alpha-Factor (LITAF) is a transcription factor that mediates TNF-α expression. To determine whether LITAF participates in the mediation of TNF-α expression in acutely inflamed colonic tissues, we first established the TNBS-induced colonic inflammation model in C57BL/6 mice. LPM were harvested from non-inflamed and inflamed colonic tissue and inflammatory parameters TNF-α and LITAF mRNA and protein levels were measured ex-vivo. LPM from TNBS-treated mice secreted significantly more TNF-α at basal state and in response to LPS than LPM from untreated mice (p
Recommended Citation
Bushell, K., Leeman, S., Gillespie, E., Gower, A., Reed, K., Stucchi, A., Becker, J., & Amar, S. (2011). LITAF Mediation of Increased TNF-α Secretion From Inflamed Colonic Lamina Propria Macrophages. PLoS One, 6 (9), 25849-25849. https://doi.org/10.1371/journal.pone.0025849
