NYMC Faculty Publications
Association of Corrected QT Interval With Long-Term Mortality in Patients With Syncope
Author Type(s)
Faculty
DOI
10.5114/aoms.2013.39383
Journal Title
Archives of Medical Science
First Page
1049
Last Page
1054
Document Type
Article
Publication Date
12-30-2013
Department
Medicine
Abstract
INTRODUCTION: The electrocardiographic parameters QRS duration, QRS-T angle and QTc can predict mortality in patients with cardiovascular disease. The prgnostic value of these parameters in hospitalized patients with syncope needs investigation.
MATERIAL AND METHODS: We retrospectively studied 590 consecutive patients hospitalized with syncope. After excluding patients with baseline abnormal rhythm, QT- prolonging medications, and missing data, 459 patients were analyzed. Baseline demographic characteristics, co-morbidities, medication use, San Francisco Syncope Rule (SFSR) and Osservatorio Epidemiologico sulla Sincope nel Lazio (OESIL) score and data on mortality were collected. The categorical variables and continuous variables of the 2 groups of patients with prolonged QTc and normal QTc interval were analyzed by Fischer's exact test and Mann-Whitney Test. A stepwise Cox regression model was used for time to death analysis.
RESULTS: Of 459 patients, prolonged QTc interval was observed in 122 (27%). Mean follow-up was 41 months. Patients with prolonged QTc interval had higher prevalence of cardiovascular disease, OESIL score, high risk SFSR, hypertension, dyslipidemia, coronary artery disease, congestive heart failure, and increased mortality. Stepwise Cox regression analysis showed that significant independent prognostic factors for time to death were prolonged QTc interval (p = 0.005), age (p = 0.001), diabetes mellitus (p = 0.001) and history of malignancy (p = 0.006). QRS duration and QRS-T angle were not independent predictors of mortality.
CONCLUSIONS: A prolonged QTc interval is an independent predictor of long-term mortality in hospitalized patients with syncope.
Recommended Citation
Balasubramaniyam, N., Palaniswamy, C., Aronow, W. S., Khera, S., Balasubramanian, G., Harikrishnan, P., Doshi, J., Nabors, C., Peterson, S., & Sule, S. (2013). Association of Corrected QT Interval With Long-Term Mortality in Patients With Syncope. Archives of Medical Science, 9 (6), 1049-1054. https://doi.org/10.5114/aoms.2013.39383