NYMC Faculty Publications
Salinomycin: A Novel Anti-Cancer Agent With Known Anti-Coccidial Activities
Author Type(s)
Faculty
DOI
10.2174/15672050113109990199
Journal Title
Current Medicinal Chemistry
First Page
4095
Last Page
4101
Document Type
Article
Publication Date
1-1-2013
Abstract
Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials. Therefore, salinomycin may be considered as a promising novel anti-cancer agent despite its largely unknown mechanism of action. This review summarizes the pharmacologic effects of salinomycin and presents possible mechanisms by which salinomycin exerts its anti-tumorigenic activities. Recent advances and potential complications that might limit the utilization of salinomycin as an anti-cancer and anti-CSC agent are also presented and discussed.
Recommended Citation
Zhou, S., Wang, F., Wong, E., Fonkem, E., Hsieh, T., Wu, J. M., & Wu, E. (2013). Salinomycin: A Novel Anti-Cancer Agent With Known Anti-Coccidial Activities. Current Medicinal Chemistry, 20 (33), 4095-4101. https://doi.org/10.2174/15672050113109990199
