Salinomycin: A Novel Anti-Cancer Agent With Known Anti-Coccidial Activities

Authors

Shuang Zhou
Fengfei Wang
Eric T Wong
Ekokobe Fonkem
Tze-Chen Hsieh, New York Medical CollegeFollow
Joseph M. Wu, New York Medical CollegeFollow
Erxi WuFollow

Author Type(s)

Faculty

DOI

10.2174/15672050113109990199

Journal Title

Current Medicinal Chemistry

First Page

4095

Last Page

4101

Document Type

Article

Publication Date

1-1-2013

Keywords

Animals, Antineoplastic Agents, Apoptosis, Coccidiosis, Coccidiostats, Drug Therapy, Combination, Humans, Neoplasms, Neoplastic Stem Cells, Pyrans

Disciplines

Medicine and Health Sciences

Abstract

Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials. Therefore, salinomycin may be considered as a promising novel anti-cancer agent despite its largely unknown mechanism of action. This review summarizes the pharmacologic effects of salinomycin and presents possible mechanisms by which salinomycin exerts its anti-tumorigenic activities. Recent advances and potential complications that might limit the utilization of salinomycin as an anti-cancer and anti-CSC agent are also presented and discussed.

Recommended Citation

Zhou, S., Wang, F., Wong, E., Fonkem, E., Hsieh, T., Wu, J. M., & Wu, E. (2013). Salinomycin: A Novel Anti-Cancer Agent With Known Anti-Coccidial Activities. Current Medicinal Chemistry, 20 (33), 4095-4101. https://doi.org/10.2174/15672050113109990199