NYMC Faculty Publications
Thalidomide-a Notorious Sedative to a Wonder Anticancer Drug
Author Type(s)
Faculty
DOI
10.2174/09298673113209990198
Journal Title
Current Medicinal Chemistry
First Page
4102
Last Page
4108
Document Type
Article
Publication Date
1-1-2013
Abstract
In the past 50 years, thalidomide has undergone a remarkable metamorphosis from a notorious drug inducing birth defects into a highly effective therapy for treating leprosy and multiple myeloma. Today, most notably, thalidomide and its analogs have shown efficacy against a wide variety of diseases, including inflammation and cancer. The mechanism underlying its teratogenicity as well as its anticancer activities has been intensively studied. This review summarizes the biological effects and therapeutic uses of thalidomide and its analogs, and the underlying mechanisms of thalidomide's action with a focus on its suppression of tumor growth.
Recommended Citation
Zhou, S., Wang, F., Hsieh, T., Wu, J. M., & Wu, E. (2013). Thalidomide-a Notorious Sedative to a Wonder Anticancer Drug. Current Medicinal Chemistry, 20 (33), 4102-4108. https://doi.org/10.2174/09298673113209990198
