NYMC Faculty Publications
New Second-Generation Long-Acting Injectable Antipsychotics for the Treatment of Schizophrenia
Author Type(s)
Faculty
DOI
10.1586/14737175.2013.811984
Journal Title
Expert Review of Neurotherapeutics
First Page
767
Last Page
783
Document Type
Article
Publication Date
7-1-2013
Department
Medicine
Abstract
Long-acting injectable (depot) antipsychotics are one approach in the management of individuals with schizophrenia. Since the introduction of risperidone long-acting injection in 2003, three additional second-generation antipsychotics have become available in a long-acting injectable formulation: paliperidone, olanzapine and aripiprazole. Although these different depot options can help with adherence and thus encourage better treatment outcomes, they differ in terms of specific indications, approved injection sites, needle gauge, injection volume, injection interval, requirements for oral supplementation, availability of prefilled syringes, storage needs and postinjection observation period, as well as potential drug-drug interactions and commonly encountered adverse reactions. After a review of the evidence base, guidance is offered on the appropriate selection among the long-acting injectable formulations of both first and second-generation antipsychotics.
Recommended Citation
Citrome, L. (2013). New Second-Generation Long-Acting Injectable Antipsychotics for the Treatment of Schizophrenia. Expert Review of Neurotherapeutics, 13 (7), 767-783. https://doi.org/10.1586/14737175.2013.811984
