NYMC Faculty Publications
Conditioned Serum-Free Medium From Umbilical Cord Mesenchymal Stem Cells has Anti-Photoaging Properties
Author Type(s)
Faculty
DOI
10.1007/s10529-013-1242-2
Journal Title
Biotechnology Letters
First Page
1707
Last Page
1714
Document Type
Article
Publication Date
10-1-2013
Department
Physiology
Abstract
Chronic exposure to solar radiation is the primary cause of photoaging and benign and malignant skin tumors. A conditioned serum-free medium (SFM) was prepared from umbilical cord mesenchymal stem cells (UC-MSCs) and its anti-photoaging effect, following chronic UV irradiation in vitro and in vivo, was evaluated. UC-MSC SFM had a stimulatory effect on human dermal fibroblast proliferation and reduced UVA-induced cell death. In addition, UC-MSC SFM blocked UVA inhibition of superoxide dismutase activity. Topical application of UC-MSC SFM to mouse skin prior to UV irradiation blocked the inhibition of superoxide dismutase and glutathione peroxidase activities, and prevented the upregulation of malonaldehyde. UC-MSC SFM thus protects against photoaging induced by UVA and UVB radiation and is a promising candidate for skin anti-photoaging treatments.
Recommended Citation
Liu, Q., Luo, Z., He, S., Peng, X., Xiong, S., Wang, Y., Zhong, X., Zhou, X., Eisenberg, C., & Gao, B. (2013). Conditioned Serum-Free Medium From Umbilical Cord Mesenchymal Stem Cells has Anti-Photoaging Properties. Biotechnology Letters, 35 (10), 1707-1714. https://doi.org/10.1007/s10529-013-1242-2
