NYMC Faculty Publications
Allogeneic Hematopoietic Cell Transplantation for Chemotherapy-Unresponsive Mantle Cell Lymphoma: A Cohort Analysis From the Center for International Blood and Marrow Transplant Research
Author Type(s)
Faculty
DOI
10.1016/j.bbmt.2013.01.009
Journal Title
Biology of Blood and Marrow Transplantation
First Page
625
Last Page
631
Document Type
Article
Publication Date
4-1-2013
Department
Pediatrics
Abstract
Patients with chemorefractory mantle cell lymphoma (MCL) have a poor prognosis. We used the Center for International Blood and Marrow Transplant Research database to study the outcome of 202 patients with refractory MCL who underwent allogeneic hematopoietic cell transplantation (allo-HCT) using either myeloablative (MA) or reduced-intensity/nonmyeloablative conditioning (RIC/NST), during 1998-2010. We analyzed nonrelapse mortality (NRM), progression/relapse, progression-free survival (PFS), and overall survival (OS). Seventy-four patients (median age, 54 years) received MA, and 128 patients (median age, 59 years) received RIC/NST. Median follow-up after allo-HCT was 35 months in the MA group and 43 months in the RIC/NST group. At 3 years post-transplantation, no significant between-group differences were seen in terms of NRM (47% in MA versus 43% in RIC/NST; P = .68), relapse/progression (33% versus 32%; P = .89), PFS (20% versus 25%; P = .53), or OS (25% versus 30%; P = .45). Multivariate analysis also revealed no significant between-group differences in NRM, relapse, PFS, or OS; however, receipt of a bone marrow or T cell-depleted allograft was associated with an increased risk of NRM and inferior PFS and OS. Our data suggest that despite a refractory disease state, approximately 25% of patients with MCL can attain durable remission after allo-HCT, and conditioning regimen intensity does not influence outcome of allo-HCT.
Recommended Citation
Hamadani, M., Saber, W., Ahn, K., Carreras, J., Cairo, M., Fenske, T., Gale, R., Gibson, J., Hale, G., Hari, P., Hsu, J., Inwards, D., Kamble, R., Klein, A., Maharaj, D., Marks, D., Rizzieri, D., Savani, B., Schouten, H., Waller, E., Wirk, B., & Lazarus, H. (2013). Allogeneic Hematopoietic Cell Transplantation for Chemotherapy-Unresponsive Mantle Cell Lymphoma: A Cohort Analysis From the Center for International Blood and Marrow Transplant Research. Biology of Blood and Marrow Transplantation, 19 (4), 625-631. https://doi.org/10.1016/j.bbmt.2013.01.009