NYMC Faculty Publications
γ-Glutamylamines and Neurodegenerative Diseases
Author Type(s)
Faculty
DOI
10.1007/s00726-011-1209-3
Journal Title
Amino Acids
First Page
129
Last Page
142
Document Type
Article
Publication Date
1-1-2013
Department
Biochemistry and Molecular Biology
Keywords
Amines, Animals, Dipeptides, Glutamine, Humans, Lysine, Neurodegenerative Diseases, Protein Processing, Post-Translational, Transglutaminases, gamma-Glutamylcyclotransferase
Disciplines
Biochemical Phenomena, Metabolism, and Nutrition | Medical Biochemistry | Medicine and Health Sciences
Abstract
Transglutaminases catalyze the formation of γ-glutamylamines utilizing glutamyl residues and amine-bearing compounds such as lysyl residues and polyamines. These γ-glutamylamines can be released from proteins by proteases in an intact form. The free γ-glutamylamines can be catabolized to 5-oxo-L-proline and the free amine by γ-glutamylamine cyclotransferase. Free γ-glutamylamines, however, accumulate in the CSF and affected areas of Huntington Disease brain. This observation suggests transglutaminase-derived γ-glutamylamines may play a more significant role in neurodegeneration than previously thought. The following monograph reviews the metabolism of γ-glutamylamines and examines the possibility that these species contribute to neurodegeneration.
Recommended Citation
Jeitner, T., Battaile, K., & Cooper, A. J. (2013). γ-Glutamylamines and Neurodegenerative Diseases. Amino Acids, 44 (1), 129-142. https://doi.org/10.1007/s00726-011-1209-3
