Endothelial Regulation of Coronary Microcirculation in Health and Cardiometabolic Diseases

Authors

Akos Koller, New York Medical CollegeFollow
Marta Balasko
Zsolt Bagi

Author Type(s)

Faculty

DOI

10.1007/s11739-013-0910-5

Journal Title

International Emergency Medicine

First Page

51

Last Page

54

Document Type

Article

Publication Date

4-1-2013

Department

Emergency Medicine

Second Department

Physiology

Abstract

Cardiometabolic disorders have been shown to impair coronary microvascular functions leading to diminished cardiac performance and increased mortality. In this review, we focus on the molecular pathomechanisms of impaired endothelium-dependent and flow-induced dysregulation of coronary vasomotor tone in cardiometabolic disorders such as obesity, diabetes mellitus or hyperhomocysteinemia based on animal experiments and human studies. We also briefly summarize the relationship among key signaling mechanisms that contribute to the development of coronary dysfunctions in these disorders, which may help develop new targets for efficient cardiometabolic prevention and treatments.

Recommended Citation

Koller, A., Balasko, M., & Bagi, Z. (2013). Endothelial Regulation of Coronary Microcirculation in Health and Cardiometabolic Diseases. International Emergency Medicine, 8 Suppl 1 (01), 51-54. https://doi.org/10.1007/s11739-013-0910-5