NYMC Faculty Publications

Efficacy and Safety of Empagliflozin in Acute Heart Failure: A Systematic Review and Meta-Analysis

Author Type(s)

Faculty

DOI

10.1080/14796678.2025.2499374

Journal Title

Future Cardiology

First Page

495

Last Page

501

Document Type

Article

Publication Date

1-1-2025

Department

Medicine

Keywords

acute heart failure, Empagliflozin, heart failure, SGLT2i, sodium glucose co-transporter 2 inhibitor

Disciplines

Medicine and Health Sciences

Abstract

Background: Acute heart failure (AHF) is leading cause of hospitalization and mortality. Empagliflozin, a Sodium Glucose Co-transporter 2 inhibitor (SGLT-2i), has demonstrated benefits in HFrEF and HFpEF, but its role in AHF remains under-explored. Objective: Assess safety and efficacy of empagliflozin in AHF. Methods: A systematic review and meta-analysis adhering to PRISMA 2020 guidelines was conducted. A search on 25 February 2025, identified Phase IIb and III randomized controlled trials (RCTs) involving adults with AHF from databases like Medline®, Cochrane CENTRAL, Embase, and ClinicalTrials.gov. Outcomes included all-cause mortality, HF rehospitalization, cardiovascular deaths, and serious adverse events. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effects model. Heterogeneity was assessed with I2 and Cochrane Q-statistic. Results: Three RCTs (n = 824) were included. Empagliflozin reduced all-cause mortality (OR: 0.47, 95% CI: 0.29–0.78, p = 0.004) and cardiovascular death (OR: 0.56, 95% CI: 0.38–0.82, p = 0.003) compared to placebo. It also lowered serious adverse events risk (OR: 0.62, 95% CI: 0.44–0.87, p = 0.005) without significantly increasing adverse effects such as acute kidney injury, diabetic ketoacidosis, hypotension, or urinary tract infections. Sensitivity analyses confirmed these findings. Conclusion: Empagliflozin reduces mortality in AHF with a favorable safety profile, highlighting need for further trials.

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