NYMC Faculty Publications

Relationship of Vitamin D to Pathogenesis and Outcomes of Hidradenitis Suppurativa: A Systematic Review

Author Type(s)

Faculty

DOI

10.1007/s00403-024-03534-8

Journal Title

Archives of Dermatological Research

Document Type

Article

Publication Date

12-1-2025

Department

Dermatology

Keywords

Cholecalciferol, Dermatology, Hidradenitis suppurativa, HS, Vitamin D

Disciplines

Medicine and Health Sciences

Abstract

Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition characterized by painful sinus tracts and significant scarring. Recent evidence suggests that vitamin D deficiency may play a role in the pathogenesis and outcomes of HS. This systematic review aims to evaluate the relationship between vitamin D levels and HS, exploring potential therapeutic benefits of vitamin D supplementation. This systematic review followed PRISMA guidelines and was registered with PROSPERO (ID:CRD42024566092). A comprehensive literature search was conducted in PubMed, Medline (OVID), and Web of Science using the keywords “hidradenitis suppurativa” and “vitamin D.” Studies were screened for relevance, and non-randomized studies were assessed for quality using the MINORS score. Due to the heterogeneity of clinical outcome measures, a qualitative analysis was performed. A total of 77 records were identified, with 38 articles remaining after duplicates were removed. After full-text screening, 8 studies met the inclusion criteria. These studies, published between 2014 and 2024, included case-control, cross-sectional, and cohort studies. High prevalence rates of vitamin D deficiency (75–100%) were consistently observed among HS patients. Improved clinical outcomes with vitamin D supplementation were noted in several studies. There were significant correlations between vitamin D deficiency and higher clinical severity, and genetic alterations in vitamin D metabolism and keratinization pathways were identified in HS patients. This systematic review demonstrates a significant association between vitamin D deficiency and HS. Vitamin D’s role in immune regulation and anti-inflammatory processes suggests its potential as a therapeutic agent for HS. However, further research is needed to determine optimal dosing and assess the protective effects of vitamin D supplementation in HS management.

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