Critical Evaluation of the Changes in Glutamine Synthetase Activity in Models of Cerebral Stroke
The following article addresses some seemingly paradoxical observations concerning cerebral glutamine synthetase in ischemia-reperfusion injury. In the brain, this enzyme is predominantly found in astrocytes and catalyzes part of the glutamine-glutamate cycle. Glutamine synthetase is also thought to be especially sensitive to inactivation by the oxygen- and nitrogen-centered radicals generated during strokes. Despite this apparent sensitivity, glutamine synthetase specific activity is elevated in the affected tissues during reperfusion. Given the central role of the glutamine-glutamate cycle in the brain, we sought to resolve these conflicting observations with the view of providing an alternative perspective for therapeutic intervention in stroke.
Jeitner, T. M., Battaile, K., & Cooper, A. J. (2015). Critical evaluation of the changes in glutamine synthetase activity in models of cerebral stroke. Neurochemical Research, 40(12), 2544-2556. doi:10.1007/s11064-015-1667-1
Originally published in Neurochemical Research. https://doi.org/10.1007/s11064-015-1667-1