NYMC Faculty Publications
Dysregulated Expression Patterns of Circular Rnas in Cancer: Uncovering Molecular Mechanisms and Biomarker Potential
Author Type(s)
Student, Faculty
DOI
10.3390/biom14040384
Journal Title
Biomolecules
Document Type
Article
Publication Date
4-1-2024
Department
Pathology, Microbiology and Immunology
Keywords
cancer, circRNA, circRNA application, circRNA function, circular RNAs
Disciplines
Medicine and Health Sciences
Abstract
Circular RNAs (circRNAs) are stable, enclosed, non-coding RNA molecules with dynamic regulatory propensity. Their biogenesis involves a back-splicing process, forming a highly stable and operational RNA molecule. Dysregulated circRNA expression can drive carcinogenic and tumorigenic transformation through the orchestration of epigenetic modifications via extensive RNA and protein-binding domains. These multi-ranged functional capabilities have unveiled extensive identification of previously unknown molecular and cellular patterns of cancer cells. Reliable circRNA expression patterns can aid in early disease detection and provide criteria for genome-specific personalized medicine. Studies described in this review have revealed the novelty of circRNAs and their biological ss as prognostic and diagnostic biomarkers.
Recommended Citation
DeSouza, N., Nielsen, K., Jarboe, T., Carnazza, M., Quaranto, D., Kopec, K., Suriano, R., Islam, H., Tiwari, R., & Geliebter, J. (2024). Dysregulated Expression Patterns of Circular Rnas in Cancer: Uncovering Molecular Mechanisms and Biomarker Potential. Biomolecules, 14 (4). https://doi.org/10.3390/biom14040384
