Design and Implementation of Multicenter Pediatric and Congenital Studies With Cardiovascular Magnetic Resonance: Big Data in Smaller Bodies

Authors

Michael P. DiLorenzo, Vagelos College of Physicians and Surgeons
Simon Lee, Children's Memorial Hospital
Rahul H. Rathod, Boston Children's Hospital
Francesca Raimondi, Azienda Ospedaliero-Universitaria Meyer
Kanwal M. Farooqi, Vagelos College of Physicians and Surgeons
Supriya S. Jain, New York Medical College
Margaret M. Samyn, Medical College of Wisconsin
Tiffanie R. Johnson, Indiana University School of Medicine
Laura J. Olivieri, UPMC Children’s Hospital of Pittsburgh
Mark A. Fogel, The Children's Hospital of Philadelphia
Wyman W. Lai, CHOC Children‘s UC Irvine School of Medicine
Pierangelo Renella, CHOC Children‘s UC Irvine School of Medicine
Andrew J. Powell, Boston Children's Hospital
Sujatha Buddhe, Lucile Packard Children's Hospital Stanford
Caitlin Stafford, Boston Children's Hospital
Jason N. Johnson, University of Tennessee Health Science Center
Willem A. Helbing, Erasmus MC Sophia Children’s Hospital
Kuberan Pushparajah, Evelina London Children's Healthcare
Inga Voges, Deutsches Zentrum für Herz-Kreislauf-Forschung e. V.
Vivek Muthurangu, University College London
Kimberley G. Miles, Cincinnati Children's Hospital Medical Center
Gerald Greil, UT Southwestern Medical School
Colin J. McMahon, University College Dublin
Timothy C. Slesnick, Emory University School of Medicine
Brian M. Fonseca, University of Colorado School of Medicine
Shaine A. Morris, Texas Children's Hospital
Jonathan H. Soslow, Vanderbilt University Medical Center
Lars Grosse-Wortmann, Doernbecher Children's Hospital
Rebecca S. Beroukhim, Boston Children's Hospital
Heynric B. Grotenhuis, Wilhelmina Kinderziekenhuis

Author Type(s)

Faculty

DOI

10.1016/j.jocmr.2024.101041

Journal Title

Journal of Cardiovascular Magnetic Resonance

Document Type

Article

Publication Date

6-1-2024

Department

Pediatrics

Keywords

CMR, Multicenter studies, Pediatric and congenital heart disease, Research

Disciplines

Medicine and Health Sciences

Abstract

Cardiovascular magnetic resonance (CMR) has become the reference standard for quantitative and qualitative assessment of ventricular function, blood flow, and myocardial tissue characterization. There is a preponderance of large CMR studies and registries in adults; However, similarly powered studies are lacking for the pediatric and congenital heart disease (PCHD) population. To date, most CMR studies in children are limited to small single or multicenter studies, thereby limiting the conclusions that can be drawn. Within the PCHD CMR community, a collaborative effort has been successfully employed to recognize knowledge gaps with the aim to embolden the development and initiation of high-quality, large-scale multicenter research. In this publication, we highlight the underlying challenges and provide a practical guide toward the development of larger, multicenter initiatives focusing on PCHD populations, which can serve as a model for future multicenter efforts.

Recommended Citation

DiLorenzo, M., Lee, S., Rathod, R., Raimondi, F., Farooqi, K., Jain, S., Samyn, M., Johnson, T., Olivieri, L., Fogel, M., Lai, W., Renella, P., Powell, A., Buddhe, S., Stafford, C., Johnson, J., Helbing, W., Pushparajah, K., Voges, I., Muthurangu, V., Miles, K., Greil, G., McMahon, C., Slesnick, T., Fonseca, B., Morris, S., Soslow, J., Grosse-Wortmann, L., Beroukhim, R., & Grotenhuis, H. (2024). Design and Implementation of Multicenter Pediatric and Congenital Studies With Cardiovascular Magnetic Resonance: Big Data in Smaller Bodies. Journal of Cardiovascular Magnetic Resonance, 26 (1). https://doi.org/10.1016/j.jocmr.2024.101041