Design and Implementation of Multicenter Pediatric and Congenital Studies With Cardiovascular Magnetic Resonance: Big Data in Smaller Bodies

Authors

• Michael P. DiLorenzo, Vagelos College of Physicians and Surgeons
• Simon Lee, Children's Memorial Hospital
• Rahul H. Rathod, Boston Children's Hospital
• Francesca Raimondi, Azienda Ospedaliero-Universitaria Meyer
• Kanwal M. Farooqi, Vagelos College of Physicians and Surgeons
• Supriya S. Jain, New York Medical College
• Margaret M. Samyn, Medical College of Wisconsin
• Tiffanie R. Johnson, Indiana University School of Medicine
• Laura J. Olivieri, UPMC Children’s Hospital of Pittsburgh
• Mark A. Fogel, The Children's Hospital of Philadelphia
• Wyman W. Lai, CHOC Children‘s UC Irvine School of Medicine
• Pierangelo Renella, CHOC Children‘s UC Irvine School of Medicine
• Andrew J. Powell, Boston Children's Hospital
• Sujatha Buddhe, Lucile Packard Children's Hospital Stanford
• Caitlin Stafford, Boston Children's Hospital
• Jason N. Johnson, University of Tennessee Health Science Center
• Willem A. Helbing, Erasmus MC Sophia Children’s Hospital
• Kuberan Pushparajah, Evelina London Children's Healthcare
• Inga Voges, Deutsches Zentrum für Herz-Kreislauf-Forschung e. V.
• Vivek Muthurangu, University College London
• Kimberley G. Miles, Cincinnati Children's Hospital Medical Center
• Gerald Greil, UT Southwestern Medical School
• Colin J. McMahon, University College Dublin
• Timothy C. Slesnick, Emory University School of Medicine
• Brian M. Fonseca, University of Colorado School of Medicine
• Shaine A. Morris, Texas Children's Hospital
• Jonathan H. Soslow, Vanderbilt University Medical Center
• Lars Grosse-Wortmann, Doernbecher Children's Hospital
• Rebecca S. Beroukhim, Boston Children's HospitalFollow
• Heynric B. Grotenhuis, Wilhelmina Kinderziekenhuis

Author Type(s)

Faculty

DOI

10.1016/j.jocmr.2024.101041

Journal Title

Journal of Cardiovascular Magnetic Resonance

Document Type

Article

Publication Date

6-1-2024

Department

Pediatrics

Keywords

CMR, Multicenter studies, Pediatric and congenital heart disease, Research

Disciplines

Medicine and Health Sciences

Abstract

Cardiovascular magnetic resonance (CMR) has become the reference standard for quantitative and qualitative assessment of ventricular function, blood flow, and myocardial tissue characterization. There is a preponderance of large CMR studies and registries in adults; However, similarly powered studies are lacking for the pediatric and congenital heart disease (PCHD) population. To date, most CMR studies in children are limited to small single or multicenter studies, thereby limiting the conclusions that can be drawn. Within the PCHD CMR community, a collaborative effort has been successfully employed to recognize knowledge gaps with the aim to embolden the development and initiation of high-quality, large-scale multicenter research. In this publication, we highlight the underlying challenges and provide a practical guide toward the development of larger, multicenter initiatives focusing on PCHD populations, which can serve as a model for future multicenter efforts.

Recommended Citation

DiLorenzo, M., Lee, S., Rathod, R., Raimondi, F., Farooqi, K., Jain, S., Samyn, M., Johnson, T., Olivieri, L., Fogel, M., Lai, W., Renella, P., Powell, A., Buddhe, S., Stafford, C., Johnson, J., Helbing, W., Pushparajah, K., Voges, I., Muthurangu, V., Miles, K., Greil, G., McMahon, C., Slesnick, T., Fonseca, B., Morris, S., Soslow, J., Grosse-Wortmann, L., Beroukhim, R., & Grotenhuis, H. (2024). Design and Implementation of Multicenter Pediatric and Congenital Studies With Cardiovascular Magnetic Resonance: Big Data in Smaller Bodies. Journal of Cardiovascular Magnetic Resonance, 26 (1). https://doi.org/10.1016/j.jocmr.2024.101041