NYMC Faculty Publications

The Critical Role of the Adipocytokine NOV in Obstructive Sleep Apnea Induced Cardiometabolic Dysfunction: A Review

Author Type(s)

Faculty

DOI

10.1097/CRD.0000000000000556

Journal Title

Cardiology in Review

First Page

554

Last Page

557

Document Type

Article

Publication Date

11-1-2024

Department

Medicine

Keywords

cardiometabolic dysfunction, endothelial cell dysfunction, NOV, OSA, oxidative stress

Disciplines

Medicine and Health Sciences

Abstract

Obstructive sleep apnea (OSA) is highly prevalent and associated with oxidative stress, chronic inflammation, and adverse cardiovascular consequences. The comorbid condition of obesity remains epidemic. Both obesity and OSA are highly comorbid in patients with cardiovascular disease including atrial fibrillation, resistant hypertension, congestive heart failure, and coronary artery disease. Patients with these preexisting cardiovascular conditions should be screened for OSA with a low threshold to treat, even if OSA severity is mild. Nephroblastoma overexpressed (NOV/CCN3) protein has been identified in multiple chronic inflammatory states, most notably in obesity and more recently in OSA, even in the absence of obesity. As such, NOV may represent an important biomarker for oxidative stress in OSA and may lead to a deeper understanding of the relationship between OSA and its clinical sequelae.

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