NYMC Faculty Publications

Mitochondrial Dysfunction in Psychiatric Disorders

Author Type(s)

Faculty

DOI

10.1016/j.schres.2022.08.027

Journal Title

Schizophrenia Research

First Page

62

Last Page

77

Document Type

Editorial

Publication Date

11-1-2024

Department

Cell Biology and Anatomy

Keywords

Bipolar disorder (BD), Induced pluripotent stem cell (iPSC), Major depressive disorder (MD), Mitochondrial dysfunction, Psychiatric disorders, Schizophrenia (SCZ)

Disciplines

Medicine and Health Sciences

Abstract

Psychiatric disorders are a heterogeneous group of mental disorders with abnormal mental or behavioral patterns, which severely distress or disable affected individuals and can have a grave socioeconomic burden. Growing evidence indicates that mitochondrial function plays an important role in developing psychiatric disorders. This review discusses the neuropsychiatric consequences of mitochondrial abnormalities in both animal models and patients. We also discuss recent studies associated with compromised mitochondrial function in various psychiatric disorders, such as schizophrenia (SCZ), major depressive disorder (MD), and bipolar disorders (BD). These studies employ various approaches including postmortem studies, imaging studies, genetic studies, and induced pluripotent stem cells (iPSCs) studies. We also summarize the evidence from animal models and clinical trials to support mitochondrial function as a potential therapeutic target to treat various psychiatric disorders. This review will contribute to furthering our understanding of the metabolic etiology of various psychiatric disorders, and help guide the development of optimal therapies.

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