NYMC Faculty Publications
Long-Lasting Sex-Specific Alteration in Left Ventricular Cardiac Transcriptome Following Gamma and Simgcrsim Radiation
Author Type(s)
Faculty
DOI
10.1038/s41598-025-89815-2
Journal Title
Scientific Reports
Document Type
Article
Publication Date
12-1-2025
Department
Cell Biology and Anatomy
Disciplines
Medicine and Health Sciences
Abstract
Space irradiation (IR) is an important health risk for deep-space missions. We reported heart failure with preserved ejection fraction like cardiac phenotype 660-days following exposure to a single-dose of a simplified galactic cosmic ray simulation (simGCRsim) only in males with functional and structural impairment in left ventricular (LV) function. This sex-based dichotomy prompted us to investigate sex-specific changes in the LV transcriptome in three-month-old male and female mice exposed to 137Cs-γ- or simGCRsim-IR. Non-IR male and female (10 each) mice served as controls. LVs were collected at 440/660- and 440/550-days post-IR, male and female, respectively. RNA sequencing, differential gene expression, and functional annotation were performed on tissues from 5 mice/group. Sex and post-IR time points had the greatest influence on gene expression, surpassing the IR-type effects. SimGCRsim-IR showed more persistent transcriptome changes than γ-IR. We suggest that the single IR effects can persist up to 550–660 days, with overwhelmingly sex-biased responses at individual gene expression level.
Recommended Citation
Zakharyan, R., Hakobyan, S., Brojakowska, A., Davitavyan, S., Stepanyan, A., Sirunyan, T., Khachatryan, G., Khlgatian, M., Bisserier, M., Zhang, S., Sahoo, S., Hadri, L., Garikipati, V., Arakelyan, A., & Goukassian, D. (2025). Long-Lasting Sex-Specific Alteration in Left Ventricular Cardiac Transcriptome Following Gamma and Simgcrsim Radiation. Scientific Reports, 15 (1). https://doi.org/10.1038/s41598-025-89815-2
