NYMC Faculty Publications
The P12 Subunit Choreographs the Regulation and Functions of Two Forms of DNA Polymerase Δ in Mammalian Cells
Author Type(s)
Faculty
DOI
10.3390/genes16020188
Journal Title
Genes
Document Type
Article
Publication Date
2-1-2025
Department
Pathology, Microbiology and Immunology
Second Department
Biochemistry and Molecular Biology
Keywords
cell cycle regulation, DNA damage response, DNA polymerase δ, DNA repair, homology-directed repair, human DNA replication, tumorigenesis
Disciplines
Medicine and Health Sciences
Abstract
There are two forms of DNA polymerase δ in human cells, Pol δ4 and Pol δ3, which differ based on their possession of the p12 subunit. The degradation of p12 has emerged as an important regulatory mechanism that controls the generation of Pol δ3. The underlying importance of this system lies in the altered enzymatic properties of the two forms of Pol δ engendered by the influence of p12. We briefly review how the balance of these two forms is regulated through the degradation of p12. We focus on the roles of Pol δ4, whose cellular functions are less well known. This is significant because recent studies show that this is the form engaged in the homology-dependent repair of double-strand breaks. We consider new horizons for future research into this system and their potential involvement in tumorigenesis.
Recommended Citation
Xu, D., Ayyamperumal, S., Zhang, S., Chen, J., Lee, E., & Lee, M. (2025). The P12 Subunit Choreographs the Regulation and Functions of Two Forms of DNA Polymerase Δ in Mammalian Cells. Genes, 16 (2). https://doi.org/10.3390/genes16020188
