NYMC Faculty Publications

Solid Tumors, Liquid Challenges: The Impact of Coagulation Disorders

Author Type(s)

Resident/Fellow, Faculty

DOI

10.3390/hematolrep17010008

Journal Title

Hematology Reports

Document Type

Article

Publication Date

2-1-2025

Department

Medicine

Keywords

arterial, coagulation disorders, disseminated intravascular coagulation, solid, thromboembolism, thrombotic microangiopathy, tumors, venous

Disciplines

Medicine and Health Sciences

Abstract

Coagulation disorders are increasingly recognized as significant complications in patients with solid tumors, affecting morbidity and mortality outcomes. Solid tumors can provoke a hypercoagulable state through the release of pro-coagulant factors, endothelial activation, and inflammation, leading to a heightened risk of coagulation disorders. These coagulation disorders may manifest as venous thromboembolism, arterial thromboembolism, thrombotic microangiopathy, or disseminated intravascular coagulation. These disorders can complicate surgical interventions and impact treatments, including chemotherapy and immunotherapy efficacy, leading to poor outcomes. Understanding the implications of coagulation disorders in solid tumors is essential for optimizing patient management, including identifying high-risk patients, implementing prophylactic measures, elucidating biomarkers for clinical outcomes, and exploring novel therapeutic agents. This review aims to provide insights into the current knowledge surrounding coagulation disorders in solid tumors and their clinical implications.

Link to Full Text

Share

COinS