NYMC Faculty Publications
The HOX Gene Family’s Role as Prognostic and Diagnostic Biomarkers in Hematological and Solid Tumors
Author Type(s)
Student, Faculty
DOI
10.3390/cancers17020262
Journal Title
Cancers
Document Type
Article
Publication Date
1-1-2025
Department
Otolaryngology
Second Department
Pathology, Microbiology and Immunology
Keywords
biomarker, cancer, homeobox (HOX) genes
Disciplines
Medicine and Health Sciences
Abstract
The HOX gene family encodes for regulatory transcription factors that play a crucial role in embryogenesis and differentiation of adult cells. This highly conserved family of genes consists of thirty-nine genes in humans that are located in four clusters, A–D, on different chromosomes. While early studies on the HOX gene family have been focused on embryonic development and its related disorders, research has shifted to examine aberrant expression of HOX genes and the subsequent implication in cancer prediction and progression. Due to their role of encoding master regulatory transcription factors, the abnormal expression of HOX genes has been shown to affect all stages of tumorigenesis and metastasis. This review highlights the novel role of the HOX family’s clinical relevance as both prognostic and diagnostic biomarkers in hematological and solid tumors.
Recommended Citation
Kopec, K., Quaranto, D., DeSouza, N., Jarboe, T., Islam, H., Moscatello, A., Li, X., Geliebter, J., & Tiwari, R. (2025). The HOX Gene Family’s Role as Prognostic and Diagnostic Biomarkers in Hematological and Solid Tumors. Cancers, 17 (2). https://doi.org/10.3390/cancers17020262
