NYMC Faculty Publications

Aortopathy: Effects of Lipid-Lowering Therapy

Author Type(s)

Resident/Fellow, Faculty

DOI

10.1097/CRD.0000000000000586

Journal Title

Cardiology in Review

First Page

82

Last Page

87

Document Type

Article

Publication Date

1-1-2025

Department

Medicine

Keywords

abdominal aortic aneurysm, aortopathy, degenerative aortic stenosis, dyslipidemia, lipid-lowering therapy, statin, statins

Disciplines

Medicine and Health Sciences

Abstract

Aortopathies can be congenital or acquired. Aortic atherosclerosis, abdominal aortic aneurysm, and degenerative aortic stenosis are some of the major manifestations of acquired aortopathy. Dyslipidemia, an imbalance of plasma lipid levels, is strongly associated with common aortopathies. A relationship between abdominal aortic aneurysm, degenerative aortic stenosis, and dyslipidemia has been identified in the literature but finding effective preventive strategies has been challenging. Nevertheless, lipid-lowering therapy remains a mainstay of both treatment and prevention. In patients with aortic atheroma, statins were found to be protective through the review of this study. There is currently no place for statins in the treatment or prevention of disease progression in patients with calcific aortic stenosis. Their low cost, widespread availability, and strong safety profile tip the risk-to-benefit ratio toward statins for abdominal aortic aneurysms but more research is needed. A review of proprotein convertase subtilisin/kexin type 9 inhibitors may yield similar benefits for all aortopathy patients; however, those results are not yet available.

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