NYMC Faculty Publications

Role of Microrna in the Risk Stratification of Ischemic Strokes

Author Type(s)

Faculty

DOI

10.3389/fneur.2025.1499493

Journal Title

Frontiers in Neurology

Document Type

Article

Publication Date

1-1-2025

Department

Neurology

Keywords

endothelial dysfunction, inflammatory response, ischemic stroke, microRNAs, neuronal death, thrombus formation, vascular inflammation

Disciplines

Medicine and Health Sciences

Abstract

Background: Ischemic stroke is a major cause of death and morbidity, and risk classification is essential for predicting therapeutic outcomes. MicroRNAs may be useful indicators for risk stratification, as they control gene expression and influence physiological and pathological processes. Methodology: A systematic strategy was developed to search relevant material using databases like PubMed, Scopus, and Web of Science. Selection criteria included human research, a certain date, or categories of studies. Data extraction, synthesis, and analysis were carried out to find trends, similarities, and differences among the chosen studies. The study’s design, sample size, methodology, statistical analysis, and any potential biases or restrictions from the selected reference papers were also taken into account. Results and findings: MicroRNA is an important biomarker for risk stratification in Ischemic Strokes. It can be used to identify Stroke-Specific microRNA Signatures, identify diagnostic and prognostic values, and regulate Vascular Inflammation, Endothelial Dysfunction, and Thrombus Formation and Resolution. It also has potential therapeutic applications. Conclusion: MicroRNAs have emerged as promising biomarkers for predicting stroke risk, severity of strokes, and clinical outcomes. They can be used to predict the severity of a stroke and aid clinicians in making treatment decisions.

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