NYMC Faculty Publications
DOI
10.18632/oncotarget.15711
Journal Title
Oncotarget
First Page
27839
Last Page
27853
Document Type
Article
Publication Date
4-1-2017
Department
Pediatrics
Abstract
Following a multivariant analysis we demonstrated that children and adolescents with Burkitt lymphoma (BL) and a 13q14.3 deletion have a significant decrease in event free survival (EFS) despite identical short intensive multi-agent chemotherapy. However, how this deletion in the 13q14.3 region is associated with a significant decrease in EFS in children and adolescents with BL is largely unknown. The gene Deleted in Lymphocytic Leukemia 1 (DLEU1) is located in the region of 13q14.3. Here, we report that DLEU1 expression is implicated in the regulation of BL programmed cell death, cell proliferation, and expression of apoptotic genes in transcription activator-like effector nuclease (TALEN)s-induced DLEU1 knockdown and DLEU1 overexpressing BL cell lines. Furthermore, NSG mice xenografted with DLEU1 knockdown BL cells had significantly shortened survival (p < 0.05 and p < 0.005), whereas those xenografted with DLEU1 overexpressing BL cells had significantly improved survival (p < 0.05 and p < 0.0001), following treatment with rituximab and/or cyclophosphamide. These data suggest that DLEU1 may in part function as a tumor suppressor gene and confer chemoimmunotherapy resistance in children and adolescents with BL.
Recommended Citation
Lee, S., Luo, W., Shah, T., Yin, C., O'Connell, T., Chung, T., Perkins, S., Miles, R., Ayello, J., Morris, E., Harrison, L., van de Ven, C., & Cairo, M. (2017). The Effects of DLEU1 Gene Expression in Burkitt Lymphoma (BL): Potential Mechanism of Chemoimmunotherapy Resistance in BL. Oncotarget, 8 (17), 27839-27853. https://doi.org/10.18632/oncotarget.15711
Publisher's Statement
Originally published in Oncotarget 2017; 8:27839-27853. The original material can be found here.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
