Altered Fractional Anisotropy in Early Huntington's Disease

Authors

Silky Singh
Hasit Mehta, New York Medical CollegeFollow
Robert Fekete, New York Medical CollegeFollow

Author Type(s)

Faculty

DOI

10.1159/000348399

Journal Title

Case Reports in Neurology

First Page

26

Last Page

30

Document Type

Article

Publication Date

1-1-2013

Disciplines

Medicine and Health Sciences

Abstract

Huntington's disease (HD) is a dominantly inherited neurodegenerative disease best known for chorea. The disorder includes numerous other clinical features including mood disorder, eye movement abnormalities, cognitive disturbance, pendular knee reflexes, motor impersistence, and postural instability. We describe a mild case of HD early in the disease course with depression and subtle neurological manifestations. In addition, we review MRI and diffusion tensor imaging features in this patient. The bicaudate ratio, a measure of caudate atrophy, was increased. Fractional anisotropy values of the bilateral caudate and putamen were increased, signifying neurodegeneration of these structures in HD.

Recommended Citation

Singh, S., Mehta, H., & Fekete, R. (2013). Altered Fractional Anisotropy in Early Huntington's Disease. Case Reports in Neurology, 5 (1), 26-30. https://doi.org/10.1159/000348399