NYMC Faculty Publications

Intraocular Schwannoma

Author Type(s)

Faculty

DOI

10.1016/j.survophthal.2012.04.003

Journal Title

Survey of Ophthalmology

First Page

77

Last Page

85

Document Type

Article

Publication Date

1-1-2013

Department

Ophthalmology

Keywords

Biomarkers, Tumor, Choroid Neoplasms, Eye Enucleation, Female, Humans, Magnetic Resonance Imaging, Multimodal Imaging, Neoplasm Invasiveness, Neurilemmoma, Positron-Emission Tomography, Scleral Diseases, Tomography, X-Ray Computed, Ultrasonography, Visual Acuity, Young Adult

Disciplines

Medicine and Health Sciences

Abstract

Schwannoma is a proliferation of neoplastic Schwann cells. Whereas schwannomas of the head and neck region are common, intraocular tissues are rarely affected. Uveal schwannoma has been aptly called a "pseudomelanoma", reflecting the difficulty in its clinical distinction from uveal malignant melanoma. Most of our current knowledge on intraocular schwannoma is limited to case reports, short case series, and non-comprehensive literature reviews. Three isolated reports of uveal schwannoma with extrascleral extension exist in literature, but the prognostic significance of this growth pattern is unknown. We present a patient with choroidal schwannoma with extrascleral extension and review 46 previously reported cases of uveal schwannomas to delineate clinical and pathologic characteristics of these intraocular tumors with a specific emphasis on schwannoma with extraocular extension.

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