NYMC Faculty Publications
Nanomedicine for the Treatment of Retinal and Optic Nerve Diseases
Author Type(s)
Faculty
DOI
10.1016/j.coph.2012.10.003
Journal Title
Current Opinion in Pharmacology
First Page
134
Last Page
148
Document Type
Article
Publication Date
2-1-2013
Department
Ophthalmology
Second Department
Pharmacology
Keywords
Animals, Genetic Therapy, Humans, Intraocular Pressure, Nanomedicine, Nerve Regeneration, Optic Nerve, Optic Nerve Diseases, Retinal Diseases
Disciplines
Medicine and Health Sciences
Abstract
The earliest impact of nanomedicine in ophthalmology is likely to involve the areas of biopharmaceuticals, implantable materials (e.g. tissue regeneration scaffolds, bioresorbable materials), implantable devices (e.g. glaucoma drainage valves), and diagnostic tools (e.g. intraocular pressure (IOP) monitors). Nanotechnology will bring about the development of regenerative medicine (i.e. replacement and improvement of cells, tissues, and organs) and artificial vision. In this chapter, we review ophthalmic applications of nanotechnology in the following areas: drug and trophic factor therapy for glaucoma, retinal degenerative, and retinal vascular disease; gene therapy for retinal degenerative disease; regenerative medicine, including optogenetics and optic nerve regeneration; and diagnostics (minimally invasive IOP monitoring). Nanotechnology will play an important role in both early-stage and late-stage intervention in the management of blinding diseases.
Recommended Citation
Zarbin, M., Montemagno, C., Leary, J., & Ritch, R. (2013). Nanomedicine for the Treatment of Retinal and Optic Nerve Diseases. Current Opinion in Pharmacology, 13 (1), 134-148. https://doi.org/10.1016/j.coph.2012.10.003
